Denosumab

BUS 690 Case #2: Forecasting Denosumab Amgen was unmatched of the humans leading biotechnology companies, with more than 17,000 employees and almost $15 billion in revenue. Amgens most important drugs forfeit in: * Aranesp-anemia; declining sharply * Epogen-anemia * Enbrel-arthritis * Neulasta-febrile neutropenia, a condition associated with chemotherapy Amgen has developed a new yield called Denosumab under brand names Prolia and Xgeva, and had patents that were schedule to expire betwixt 2017 and 2023. Prolia treats Osteoporosis, a study disorder, common scarcely serious condition. Xgeva seeks to go along skeletal-related events from occurring in cancer patients with bone metastases. Prolia Osteoporosis is diagnosed by BMDbone mineral density mental test, the indigenous BMD test was dual-energy X-ray absorptiometry (DXA); a BMD test costs $50 per patient. Amgen priced Prolia at $825 per injection, or $1,650 per year. There is a t otal of 30.7 one thousand zillion people in the U.S. with osteoporosis or osteopenia, and 15.5 million (49%) were diagnosed, only a portion of that group received intervention. 40% of patients receiving interference continued to see declining BMD levels, and 5% had fractures.

Aside from discussion options of exercise and dietary supplements, bisphosphonates are the main class of drugs for the interposition of osteopenia and osteoporosis in early 2011, made from two phosphonic groups. The drugs worked by ineptness the breakdown of bone by osteoclasts, resulting in an increase in BMD and a decrease in fra ctures. Despite the strong readiness of ! bisphosphonates, compliance was low; studies indicated that about 50% of patients discontinued oral examination bisphosphonate therapy within the first year. Prolias competition: | U.S. sales (mil) | division| Boniva| $600.00 | 2008| Reclast| $579.00 | 2010| Evista| $682.00 | 2009| Forteo| $518.00 | 2009| Total U.S. sales of competitors:| $2,379.00 | | Prolia is administered by...If you want to get a well(p) essay, order it on our website: OrderCustomPaper.com

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